hmmm... well the only 4 wheel drive hobby grade RC iv owned was a nitro TC. and my other 2 on road cars are 2wd. one's a tamiya M03 chassis which is front wheel drive. the others a pan car. all 4 of my off road cars have been 2wd stadium trucks.
iv always kind of preferred 2 wheel drive for off road. it just fits my driving style better. i tend to throw the rear end around and steer with the throttle. iv bashed friends 4wd cars and (excluding monster trucks and 1:8 scale) i saw no real benefit to having those 2 extra drive wheels.
on road, who cares. hauling ass up and down the street is hauling ass up and down the street. iv never found one to be better than another. with a halfway proper tune they are all pretty much equal when it comes to bashing.