I've both played the game (and loved it) and thought about just this subject.
There'd have to be some basic changes made to many of them. Being virtual many of the designs are just not practical either from the standpoint of basic aerodynamics or just from having an engine that is totally out of place from the mass moment arm point of view. Also there would have to be some poetic license taken to adapt most of them to landing gear...... Unless you're thinking of a 1/4 scale airship to launch from and recover too....