For the carb setting, it would be good to know what kind of engine it is. Some engines are different, but for most .40 to .60 size engines, about 2 1/2 turns out (ccw) from the closed position is a good starting point. As far as the optimal setting, you have get the engine running and tune to find it, and it can change a little due to temp, elevation, etc. If you get it started while set at 2 1/2 turns out, slowly, slowly, slowly, turn the needle in (cw) to lean it out to max rpm, then back off 300 to 500 rpm, usually 3 or 4 clicks. That should get you close enough to fly, but unless you are a seasoned expert, a tach of some sort is the best way to get the engine tuned properly.
If you're not an experienced Rc pilot, I would highly recommend you find a club or someone who is experienced to help you out and help you put it in the air.