If you are right handed and your plane spends all of it's time torque rolling, then mode four would seem to be the best for this.
Likewise if you are left handed mode 1.

But if you want ease of learning, and right handed controls that are closer to what you would see in a real plane, then mode 2 is favored.

e.g.

Pushing and Pulling a full size plane's "control wheel" lowers and raises the elevator, while turning the wheel moves the ailerons... just like the right stick in mode 2.
The rudder is controlled by your feet as it is less frequently used once in the air, so mode 2 mimics this with the left hand left/right stick movement. etc.