Really hard to say either way as you did not mention the type of plane. I would suggest listing the plane model and asking if anyone else needed to set it differently.

I'd say it would depend on the type of plane, and what your plan to due with it. If it's just a sport plane or slow flyer and you just want something to fly go with the 2 down 2 right.

If your planning on competition or just wantto set it asaccurate as possiblethen you will be flight trimming. If it's a proven design then start at 2 and 2. If not, start at 1 and 1 then adjust as needed fromflight trim tests.

I would not recommend setting the thrust at 3 anything to start. I have a 50FSR on a Kaos, not built by me, that had 4 down 0 right and after getting to the point where I was stacking washers I decided to just shave the back of the motor mount on my belt sander. Was a major PITA to fix as I had to make alot of extra flight trim tests to get the thrustwhere it needed to be.