Last weekend we had someone who actually was hindered by a simulator.

They configured the radio with most of the controls backwards and learnd to fly that way. They came to the field with the plane set up backwards also.

I could understand the elevator being backwards. A noobie might think stick up is "up". But they had the ailerons backwards also.

They did not do well in flight, but no problems. We sent them back home to learn the simulator the right way.