A one inch offset of the engine in this way would most certainly be noticeable in flight. Turns in one direction would be snappier than the other and if knife edge flying was tried the model would handle noticeably different from one side to the other. Even wing overs would be quite different from one to the other side.

In short don't do it. If you want to side mount the engine instead of inverted then add a Pitts style of cowl to the nose to cover the engine. The air from the cowl can exit the back along the side of the fuselage. That way you can mount the engine ON the centerline like it most definitely should be located.

And build in about 1.5 to 2 degrees of right thrust.

Keep in mind that the idea behind down and right thrust settings have been tested and proven time and again going back to before many of us were born. You ignore such "rules of thumb" at your own risk.