Center your trim lever or knob. Put a little "L" for lean and a "R" rich on your control. Set up your carb's inflight control so you have bind free, equal travel in both directions. Tune your carb like normal (Novarossi uses a small flat blade screwdriver for the needles). Once you have your base settings set (little rich) get it in the air.

My personal experience with the inflight mixture control is it is great for plane designs that will not allow an "ideal" tank setup. This usually means that you half to richen the mixture as the fuel level goes down in the tank. It can also be used as a fine tuning tool while flying to get everything out of the engine..... but I never trusted myself for that kind of "lean" adjustment while the plane flies by a full throttle....

Hope this is what you are looking for.