Ed,
I expect you will get lots of input on this......
By low RPM, I suspect low throttle setting is meant, rather than a richer than usual mix. The intent is to reduce loads on the rod during the first few minutes of run time.
You might consider removing the back plate and putting some oil directly on both ends of the rod before the first start; also, I have used my covering heat gun to evenly warm up the upper cylinder area before the first start. (NovaRossi Speed 13 engines)
I would definitely make the first runs on a test stand so that the process can be better controlled.
How tight is the piston fit on these engines?