I used the simulator for several months and then had a buddy box for my first day. My plane was a .46 trainer. Big is GOOD!
An E-Flite Apprentice is a good choice.
For me, the noticeable differences between Sim and actual flying:
1. There isn't a reset button; don't be surprised if your hands are a little shaky.
2. Unless you're at a very large flying field, you will quickly cover ground faster than you practiced in the simulator; more frequent turning.
3. As previously mentioned; WIND/Air Movement/Thermal.
4. Mechanical failures are REAL. Double check all fittings and test your equipment. Watch for binding at control surfaces.
5. Servos: Slop/Play, control surface movement, control horn/rod placement.
6. Vision; you CAN safely look away from the computer monitor while flying if you're distracted....this is NOT something you can do while flying R/C. If there's a bee flying around you, get your spotter to help out. Keep your eyes on the aircraft at all times.
7. Watch your fingers; a simulator won't remove skin but a real propeller will.
8. Senses; the human body is a complex machine, more so than your simulator. I'm envious of you for what is coming. The sights, sounds, smells....all new to you!
9. You WILL have a bigger smile flying real R/C compared to your simulator
Good Luck and Clear Skies. Let the community know if you need anything and feel free to share your experiences!
-PD