What aeroplane?
First thing I do is fly, trim and balance ( match) the control feel. This gives you a clue on gyro set up. I'm very new to aeroplane gyros to, but it was obvious to me that you would not get the best out of a gyro like the 3e without setting the gains to suit the control power. On an Xcalibur the elevator is much more powerful than the ailerons, so reducing the gain 20% in the gyro settings will allow a high overal gain setting.
Expo generally needs reducing 50% od what you had before the gyro was set