Looking from the top.. plan view.. a misalignment between the wing and tail will have a slight effect for a small offset.
Looking from the front...Tilting the tail relative to a horizontal reference results in the plane turning towards the high side... That's how birds turn.
In a competition airplane, any physical factor that departs from optimum is bad. These can require trimming of the control surfaces which add drag, and an airplane that changes response with airspeed.