The way I see it is if you run 4 2s, 2 of them in series and 2 of them parallel you should be ok if I'm understanding your question correctly. I'm no ESC guru so let someone else chime in, but think about it like this...if you have an esc capable of 2s you can run 2 2s in parallel to keep the voltage the same and just adding capacity. The esc still reads it as a 2s and voltage, LVC, etc should still be good.

Some on the subject here.
https://www.rcgroups.com/forums/show...ries-in-series