Hi,
The other engines are only angled to compensate for a engine loss in flight. If you loose an engine you need to be quick to close the the opposite inner/outer. I suggest that you do not try to fly it without twin throttles (inner pair and outer pair).
The plans indicated CG is fine. You will probally need some lead in the nose.
Mine flew with four old OS .25's (Pre FP) and this is enough power. It would be great with .26/.30 four strokes. Set each engine for individual reliability and ignore trying to match RPM's. Reliability is way more important!
The rudders do not "bite" very well untill the model has got some ground speed. Other wise it is like a trainer to fly in flight. You must keep power on for landing or the elevatior lacks effect.
I never had flaps in my Lancaster/Manchester so I do not know what that would be like.
I never had the ailerons raised, they was always inline with the wing.
My dad flew a scaled up version of this Lancaster (12 foot span). He wrote an article on how it flew and its demise on my club website (sorry about the ads, tripod ruined the site):
http://corsairmfc.tripod.com/lancaster.htm
Hope that helped,
Alan