I'm no expert but isn't the difference in remaining capacity more of a function of capacity than voltage?

IF that is the case would it make more sense to fly 10S 6000 vs. 12S 5000? I get that if the voltage is higher the throttle is lower and consumption will be lower but you could accomplish the same thing using a higher capacity pack. if you use 4000mah a flight that is 80% of a 5000 pack or that same 4000mah is roughly 67% of a 6000 pack leaving more safety capacity and less heat.

I am asking for my own edification not pretending to understand or pick a side.