FSOne can use anything that shows up in Windows as a Gamepad/Joystick, so as long as your old Interlink uses USB (and not the really old parallel port!) it will work. For either connection, it does require the addition of two additional (free) programs to remap/scale the Inputs from Windows into something useable by FSOne. They give full "how to" instructions. Those of us using OpenTX/Edge (and probably Ethos) radio systems don't need the two remapping programs as we can pre-configure our radios.