Of course anything that runs harder will wear out faster. I used to run my TT46 and SC46 on Tornado fuel 30% for gas powered cars. I can turn a 11x6 at about 13,500 RPM w/o a tuned pipe (I live at the Equator so thats pretty decent as it gets really hot and humid here). Now with a tuned pipe and 15% its turning easily 14K rpm (I have not shortened the header by that much yet) on an 11x6.

a 10x4 is not a good choice, you end up with so much RPM that the prop is no longer efficient, so called RPM to Thrust ratio is no longer practical. For me its a 10.5 x 7 and I find that a great prop for speed and yet retain some decent torque. Of course your 11x6 is just a safe bet.