If you can look at the prop and see that the hole is off center, don't use it. Return it or pitch it... or use it for stirring paint. A couple of years ago, I got a batch of APC's that were off center and sent the props to them. APC replaced them and threw in a couple extra for my trouble.

Normally, props are going to be, very slightly, out of balance at the hub. The forces generated will be very small and can be pretty much ignored, even on an engine turning 20,000+ rpm.