Wow, nothing like a simple question. You will find that the planes fly "Heavier" than single engine planes, in general, due to higher wing loading. Do not do a tail dragger to start with. The engines almost never come up together and this really can make a handful as you start. As stated above, not so different.........UNLESS ONE ENGINE GETS A SERIOUS CASE OF QUIET.
It is usually a good idea to hold a single engine plane up to check engine performance. IT IS MANDITORY for a twin. Lose and engine on take off and you lose the plane.
My two cents are detailed in our sister site at rcwarbirds.com and the technique section.
Good Luck,
Twinman
PS Now, if we have not scared you........nothing is so cool as the sync of two or more engines in the air.