The suitability of a 2-stroke for profile use has a great deal to do with its performance range and design.
Jett offers two excellent 3D engines in the "40" size class. The SJ-61H and the BSE-76L. Both are designed from the start for use with bigger props, lower rpm, superiour midrange torque, positive fuel draw and linear throttle response. Either engine weights about the same as an OS46FX. No special fuel.... normal 10-15% sport fuel.
So basically you get similar performance to a 4 stroke, but the smoothness and compact footprint of a 2 stroke.
61H typically turn 12.25x3.25, 12x4 and 13x4 props.
The .76L is set up to run great with 13x6, 14x4W, 14x6 (shown below). The BSE-120 is the "60 size" version of the 3D engines.
I trust this is helpful.
Bob