Yes, but believe it or not, your plane will fly better if you take the time to do at least a little mechanical trimming. For example, if you use EPA to drop your control down more than about 85% throw, consider moving out on the control horn on the surface in question. It's better to use all the servo resolution and leverage you can get, and that means 100% of travel if possible. Since you also want to be as far out on the servo arm as you can get with in reason, that means you're best limiting travel at the control surface.

In a simular vein, you want the pushrod to leave the servo at a 90 degree angle. (most of the time, if you intentionally want more throw in one direction than another, that's different). If you subtrim a servo over to get something centered, then you're better off adjusting pushrod length and servo arm location.

Also note that most (but not all) servo brands have an odd number of teeth in the output spline. That means that if the arm isn't lining up at 90 degrees for neutral, try flipping the arm around 180 degrees, it might just start lining up right. (Hitec, I think, is the big one that likes to use an even number of teeth, so this doesn't work on some of their servos).