I don't see why it shouldn't work, when you take into consideration that denatured alcohol is PURE ETHANOL + METHANOL no water, my mixture of 60%gasoline + 35%E85 + 5% nitro will give just about the same proportions of 65% gasoline +35% denatured alcohol +5% nitro. (E85 fuel is 85% Ethanol + 15%gasoline and if my math is not wrong 15% of 35% is = 35% x .15 = 5.25 gasoline, so that will make my mixture at 65.25% gasoline + 29.75% Ethanol + 5% nitro), just make sure you make your fuel mixture at these proportions then go ahead and treat the whole mixture at a 40:1 or 50:1 oil content ratio if you use amsoil or any other good quality synthetic oil (Mobil's MX2T racing oil or MAXIMA motorcycle synthetic with castor or VP racing castor oil)