The one issue that tends to be glanced over in the use of vortex generators is design. Simply applying randomly sized and placed bits to the wings of any given aircraft and expecting improved performance is craps shoot at best. Companies such as Boeing, spend millions of dollars in wind tunnel testing and computational fluid dynamics studies to get the vortex generation sizing and layout just right. Factors such as airfoil design, surface roughness, and control surface location come into play during the studies. More focused on the vortex generator itself, designers look at height, placement, orientation to the free stream, and more.

Like winglets the use of vortex generators is espoused as a major perfomance improvement, however as the addage goes - you never get something for nothing. Often times added weight or unintended control surface flutter degrade performance benefits gained from adding vortex generators, or winglets, or...

All that being said, the great thing about this hobby is that it never hurts to experiment, in fact that is half of the fun in my mind. Best case scenario you improve the performance of your plane and you learn something new. Worst case scenario you get to build a new plane