You can use the 2-in-1 to switch over to a regular radio and use the brushed motors. You will need to have a receiver and a separate gyro to accomplish this. This is not a bad thing though as the gyro in the 4-in-1 is barely adequate.

If you want to go brushless then you will need a separate esc for the main motor. You can do this easily by connecting the brushless esc to the throttle connection on your receiver, connect the main now brushless motor to that esc, connect your gyro to the receivers rudder output, connect the tail motor input on the 2-in-1 to the gyro, connect the tail motor to the tail output on the 2-in-1, this will give you a brushless main and proportional control of the tail motor.

The other servos are hooked up normally.