There is no good answer for that question.

If you go to my gallery you can see my DC-3 which has Inverted Saito 100s running from a central tank in the fuselage through Iron Bay regulators.

The Thunderbird is an Inverted OS fourstroke using a Dubro fueler and no glo heat.

The best way for me has been to start out with the least complicated combination and then add components until it performs to my expectations.