Nah... you may lose some of your precision, if you ever had any... but the basics come rushing back.
I stopped flying for 10 years, and was scared to death of that first flight back...
to the point of purchasing an Advance 40 as my "re-entry" bird.
The first flight was very exciting... complete with knee-knocking on my first landing, even though
it was a nice "greaser" type landing, after one "missed approach" overflight.
Still... after 3 more flights, I found I'd been worried for nothing, and was bored with the plane already.