Im not real sure how the 2 in 1 works. But like a plane the RX takes its power from the lead that comes from the ESC. So if the 2 in 1 is an ESC then it should be the very same.
I love the fact that the Spektrum is glitch free. And for a heli as jumpy as the Blade CP I think glitch free is the way to go. Im putting together an MX400 right now that will be run with the DX6. I was going to go with a better heli radio but Ill probably never be running a big nitro bird so I dont need all the extras that come on the Futaba. And I still like my planes so the DX6 allows me to fly both.