Yes, run them in at full throttle because it's not the same as a car or motorbike (if that's what's giving you concerns) where you'd never drive them flat out straight from the showroom .

If this is the first time you've run an engine then you mightn't know the different sounds an engine makes when it's either 4 stroking or 2 stroking. When it's 4 stroking the exhaust note is like a lowish growl with quite a lot of white smoke but 2 stroking is a much higher pitched steady "scream" with less smoke. You should remember that a lean setting is bad for the engine, even after it's run in, but there's a couple of easy ways to check if it's rich or lean. Start it up with the needle wound out the 2 turns as they say, go to full throttle and wind the needle out a bit further (maybe a 1/4 turn). If the revs drop then you're on the safe (rich) side. Or after going to full throttle you can pinch the fuel line closed for about a second or less. If the revs rise for a moment then you're running rich but if you keep the line pinched for too long then the engine will just starve for fuel and stop.

As a guide line for your engine, and it really depends on what size prop you use, it'll be on the break point between 4 stroking and 2 stroking at around 10-12000 revs.