Real planes other than fighters generally have a far poorer power to weight ratio than even our average models. Due to that the difference in taking off and landing in the correct direction is FAR more important. Even some of our models will suffer from issues if you do things the wrong way. I don't think any of us would argue that taking off and landing WITH the wind is a good thing to do on a regular basis. I know I sure wouldn't.

But that doesn't mean that it can't be done if you have enough room and enough power.