Be careful not to start it with an electric starter flooded (if starting inverted). Also if the tank height is positioned properly it should run fine upright or inverted. The problem with an inverted engine usually is fuel syphoning into the engine because the carb is lower than the tank. In this day when most start thier engines with electric starters, as opposed to by hand, the likelyhood of damage from a flooded engine is much more likely.