Matters a great deal, but not usually to the point of a major control issue. More in roll rate to one side vs. the other and trim settings. Usually caused by differences in wood density or the amount of glue applied.

Balance the model with the wings in place by either hanging it from string around the prop shaft and to either a pin in the trailing edge near the centerline of the rudder or looped under the tail wheel (if so equipped). If one wing always dips first add weight to the high wing tip. Washers or lead shot set in epoxy (after opening the outermost wing panel or tip covering.

If you don't want to cut the covering you can wrap electrical tape around an aileron servo with as many Lincoln cents as needed. You'll need more weight than if added at the wing tip.