OK got it, In other words it looks like most of my airplanes!

If the wing and tail are horizonta/parallel to each other and if the vertical is 90 deg relative to the horizontal I would ignore it. The fuselage is just a stick holding the wing and tail in position and the slight cant, while noticable visually, probably won't be noticed in just flying around.

I am sure if we had a perfect version of it that the difference in flying would be noticable but I would guess a few clicks of trim would take care of any input the fuselage has.

If it were a pattern airplane I would suggest making everything true but not for a fun fly. It will fly just not be perfect.