2-stroke v-twin is possible if it is a port induction and not reed valve. You will have to have two carbs and two fuel systems, or at least two clunks in the tank. It would also require a pressurized fuel system, or suction feed since the two pistons would cancel out changes in crankcase volume to operate a walbro type pump. It is probably not effective, but I think it is possible. It would sound like it is turning twice as fast as it really is since there would be two power strokes per revolution.