If your engine spins the proper way and you can mount it to the plane and mount a prop on it. Sure! I'd watch the RPM so you don't scatter a prop though. I don't know what those engines are rated for, but I'd think 13,000rpm is the max I'd run a prop. You can use a larger diameter prop to load the engine to a rpm range.

I imagine you'll have to lean the engine out a lot. Car engines have huge cooling fins due to the relatively low airflow. On a plane, the engine will probably run much cooler, so you'll have to lean the engine for it to run properly. I think?

I'd sound wierd though. I'll bet you'll get a lot of strange looks and questions. I can't think of a reason it won't work. I bet it'll make a mean 200mph plane.