Well, usually you tune for the best power, minus a bit to give it good lubrication.. regardless of the altitude. You will naturally lose power as you gain altitude, but I don't imagine that being just a few hundred feet over sea-level will cause as much as say, living in Denver, for instance.

In your case, 2200 feet asl, well, it probably will require a bit of retuning.. but that would be nothing different than you would do from day to day or week to week at sea-level as air pressure changes by normal weather patterns.

CGr.