4-Stroke engines burn considerably less fuel than a comparable 2-stroke. I own one 2-stroke that is bigger than a 46 and that is my OS 75AX. Aside from that, everything I have larger than a 46 is a 4-stroke (Or a gasser).

Better torque, less fuel, and MUCH less mess.

And they are no more difficult to tune than a 2-stroke is. As far as I am concerned, there is only ONE disadvantage of a 4-stroke and that is that they are more expensive than a 2-stroke. But you'll save the difference in one season with the savings in fuel.