Yeah.... it will fly a whole lot better. With all the training aids off it will be a fair bit faster but that is what the throttle is for

. You will also have to retrim the elevator some. With the aids on, the NexSTAR had a lot of extra lift so
down elevator was the normal for level flight. With all the aids off, a "slight" bit of
up elevator will have to be set. If not, you may end up in the weeds at the end of the runway(ask me how I found this out).
Bigger wheels will not be noticeable, or the extra weight. I run 3.25" wheels on mine and love them. I never noticed anything wrong with the wing incidence after removing the dihedryl. She still flew great.
As far as take offs and landings, I don't think you will notice a huge differance. This plane lands and takes off great with or without the aids. The plane will roll crisper, do nicer loops and inverted is a heck of a lot easier also. Do not be afraid.... just go fly it!!
Here are a couple pics, again, just to re-wet your apetite for a taildragging DragSTAR!!