Not much, as long as the heights are appropriate. Too low and any time you pull positive gees (i.e. every time you pull back on the stick) you'll drive the mixture lean. I imagine you dealt with that at installation time though.

If the issue is not cooling air flow, as suggested, reduce nitro. Just try it, you really should eliminate that variable to reduce guessing. Maybe you can borrow a tank or two? Preignition can occur if you use the higher end of the allowable nitro range, and you use a hot plug and if weather conditions are not helping.

As to running full throttle all the time - that should not matter one iota. It has to work there or you need to fix something.

MJD