Not unless there is something wrong with your Gas/Glow fuel. Water? Old gas? Otherwise, they will definitely run MUCH better on the Gas/Glow mix than on straight gasoline.

I use a mix of straight gas (actually Coleman fuel) with Sta-bil & Pennzoil in my engines after flying to clear out any alcohol still in the carb or engine before I store my planes. They run MUCH "rattier" on this mix than the Gas/Glow fuel.

AV8TOR