The natural drift, turns, etc are going to cause some altitude change. Do you use aileron to achieve that altitude change? I know some people (maybe most) use this method.

On the multiplayer machine I've watched some people that use the rudder for altitude adjustment. You have to make sure that any roll coupling is mixed out though, or the aileron duties are much more onerous

I've practiced both ways, on the sim, and with a real plane, and find pros and cons with both.

One of my concerns with the Predator was increased roll coupling because of the 95-100 degree tail versus the usual 110 degrees. A Predator flyer has confirmed that there is indeed more roll coupling than usual. Of course, you can mix it out, but then that's more drag and on a V-tail adds a dimension of trim variables.