RE: Large 4 engine project!
If I were you, My ESC would be as close to the batteries as practical as this eliminates the need to run the leads from the receive{servo leads] out there and I think this is recommended practic. It also means that the ESC is somewhere you can get at it for replacement, and you nacelles get very simple without lots of hatches or shells to remove. Your e;lectric motors will most likely be removable out the front without going into the nacelles after the nose cone is removed. I am working on a 1:10 scale P-3 Orion currently and that is my plan..