In my experience I have found most average sized 2 strokes will probably run fine on 10 or 5 or even 0% nitro but you have to be willing to put in the effort to tune them for it and most flyers are not content fiddling with their engine when they could be flying.
Imyself love tuning up my engines to get the most of my combos. Ihave become the go to guy for tuning engines at my field.