I put my evolution 46 on my tribute. I can get it tuned on the ground at full throttle but when I pick the nose straight up it starts to serge. So I tune it again and get it to running good both ways on the ground, but after take off it starts to serge. I put a new A-3 plug in it and a tower muffler on it. Need help

It sounds like an air leak somewhere. I would carefully check and/or replace all the fuel line, including inside the tank.

Good choice in plugs and muffler!

The fuel line from the remote needle valve to the carb is the first thing I would replace. Is the carb tight in the crankcase?