I have a new Stealth Conspiracy 220 and I had it hooked up to betaflight. Well the channel mapping was all out of whack so I switched a few settings around and now I CANNOT connect to beta flight. If I start up in reboot mode, I can flash betaflight successfully, but then after that if I try to connect it says "serial port opened successfully" then a few seconds later "serial port closed successfully."

I've never been so frustrated in my 15 years in the RC hobby. Is there a way to just "start fresh" with these things?

Yes. Turn the ON/OF switch to the OFF position, throw it in the trash and buy a new one.