I've searched the web unsuccessfully for a RC flight simulator that utilizes an actual transmitter platform for a Mac operating system.
Any suggestions?

I have a macbook pro plus various pc laptops. I just use my pc laptop to run realflight. Surely you could find a cheap used laptop that could run it for you. When I say cheep I think 100-200 at the most would be perfect.

Thats probably going to be my only option in order to get a good realistic simulator that uses an actual transmitter.

Aerofly Pro works with the Mac and your transmitter and correct sim cable.

If you install VMware Fusion (<$100) and a real copy of Windows 7 or 8 in a VMware Fusion virtual machine, both Phoenix and Realflight work fine. You should have a pretty powerful Mac though. I allocate 2 cpus and 8 GB of RAM to the vm that I use for running the simulators. Nice to have the high def 27" iMac screen to run the simulators.

Thanks Michael