RE: 2.4 poll - Requesting pilot experiences
Absolutely! Bottom line up front KNOW YOUR VOLTAGE REQUIREMENTS!
When I made the switch to 2.4, I had a momentary lock out on my 50cc plane, but recovered. I also locked out a .60 size electric. It was a hard hit, but re-buildable. Both of these were due to my own lack of understanding of the voltage requirements of 2.4. I made the improvements and have had ZERO lock-outs since.
I also have one RX that seems to need re-binding all the time. It probably is somehow related to all the crap I have plugged into the receiver (lights, gear, and flaps on servo regulators). Either way, I just make sure I have a good link before each flight and have had no problems in the air.