Yes, Aerofly pro will work with Windows XP and a USB port.
I purchased a used Belkin Serial/USB adapter on Ebay for $6.
It worked great on my laptop - Compaq 910, AMD 1.5, Radeon mobility. Being a senior I am very computer challenged!!!!!!!!!!!
It took several weeks of communication with RCU and Ikarus, Germany before I got it operating. When I finally got it installed and working I decided it wasn't worth the effort and sold it!!!!!!!!!!!!