Yes...I have.

It doesn't really matter if it's heli, airplane, or even car fuel. What matters is the oil content, the nitro content, the oil type, and the quality.

For "most" 2 strokes (O.S., TT, Magnums) you want around 18% oil. I would never use less than 18% and am glad to use 20% for the extra protection.

As far as nitro content goes, anything from 5% to 15% is fine without making any physical changes to the engine.

The difference between heli fuel is that it's usually all synthetic oil, as opposed to a castory/synthetic blend. That means, no castor. If you end up running it a little lean, or storing the engine without after-run oil, the synthetic won't protect like the castor oil. I don't know how true that really is, but from my own experience, I'll ALWAYS use castor.

The disadvantage is that the castor oil makes a mess..

The fuel I use is a 80/20 blend of synthetic/castor... That is what I recommend.