Hello there. While I have not a bipe, I do have a number of S.Bus models including 2m. After setting mechanical linkages on a new model, I fine-tune the centering in the servos. After rounds of trim flights, I program the resulting trim into the servos so that there is no sub-trim, and little to no trim on the radio. This in my mind minimizes the problems if one were to take off on the wrong model, and eliminates the possibility of reversing ailerons as the channels are also programmed into the servos. The single S.Bus cable per wing is a big convenience for a bipe I'd imagine; and I enjoy it on two scale sport monoplanes with single piece wings. The other nice thing is that if one is re-trimming during a flying session and wishes to discard the changes, just go back to zero.

P.S. On a bipe, I would probably just stick with my usual Ch.1 for the left, and Ch.6 for the right ailerons; bipe guys may recommend otherwise if there is an advantage to 4ch.