You will be bombarded with Spektrum suggestions but I suggest you spend some time researching the major brands. All have their strengths and weaknesses. If possible visit hobby shops or flying sites to touch and feel what is available and try to touch all brands you can access. Many fellows have purchased the latest wizbang only to find it's ergonomics or operations don't work for them.
Budget should be taken into account plus type of flying you plan to do. Many will suggest purchasing the highest level of system so you can grow into it with future flying machines. Not a bad suggestion if you have some idea of future plans but budget may limit things for now.
Since you are returning to the hobby look to major brands (Futaba, JR, Spektrum, Graupner) that have been around for some time rather than the off shore cheap systems that offer a lot of bells and whistles but spotty reliability. I am a long time radio nut so have tried almost every brand out there including the off brands. Major brands all work well and have service centers available. Off brands range from pretty good to plain junk.
Programming transmitters is a learning experience, some are easy, some not. Some features are very handy but too many can confuse the learning curve and you may never use them anyway. If you plan to go outside of the BNF models, learning the programming is a must.
Take some time before deciding. Good systems aren't cheap so don't rush into making a purchase that you may regret.